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Research projects

This section of the ME/CFS Research Register (beta version) provides an overview of past and ongoing research projects on ME/CFS, starting from 2019. Projects include basic, clinical and epidemiological research. Click on a project to see its description and further details including research areas, types, and networks, as well as working groups, selected people, publications, and organisations (hosting involved working groups) connected with the project. Use the search function to look for specific topics, areas or types of research, for example. A description of the register's current scope can be found on the starting page (Home).
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60 of 60 research projects

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ACT-CFS Pilot Study - Pilot Study to Evaluate an Innovative Activity Scale for Children and Adolescents with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Altered Endothelial Dysfunction‐related miRs in Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
Analysing Antibody Responses against EBV-derived Antigens in ME/CFS
Project status:
Completed
Country:
Poland, UK, Germany
Principal investigator:
Carmen Scheibenbogen, Nuno Sepúlveda
Organisations:
Charité – University Medicine Berlin, Warsaw University of Technology
Research period:
2020-10-01
to not available
Research types:
Basic research
Research areas:
Infections, Immunological dysfunction
Analysis of Blood Immune Cell Transcriptomes by Single-Cell RNA Sequencing (scRNA-seq)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-10-01
to not available
Research types:
Clinical research
Research areas:
Hemic and lymphatic system disorders, General
Analysis of Differences in Plasma Proteins Using Mass Spectrometry
Project status:
Ongoing
Country:
Germany
Principal investigator:
Markus Ralser
Organisations:
Charité – University Medicine Berlin
Research period:
2022-10-01
to not available
Research types:
Clinical research
Research areas:
General
Analysis of Serum/Plasma Markers and Changes in Cellular Composition and Activation of Blood Cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2022-10-01
to not available
Research types:
Clinical research
Research areas:
General
Application of Direct Current Transcranial Stimulation, Remotely Supervised in Chronic Fatigue (ACTIVATE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Berthold Langguth
Organisations:
University of Regensburg
Research period:
2023-03-16
to 2025-01-31
Research types:
Clinical research
Research areas:
Nervous system disorder
Association Between EBV Reactivation and Development of Long-COVID Fatigue
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayer
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Basic research
Research areas:
Infections
Autoantibody-induced Transcriptome and Proteome as Biomarkers
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gabriela Riemekasten
Organisations:
University Clinic Schleswig-Holstein - Luebeck (UKSH)
Research period:
2022-08-01
to 2025-07-31
Research types:
Basic research
Research areas:
Immunological dysfunction
Autoimmunity Risk Variants in the PTPN22 and CTLA4 Genes are Associated with Infectious Onset of ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Sophie Steiner
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immunological dysfunction, Genetic risk factors, General
Bavarian Network for Researching ME/CFS (BAYNET FOR ME/CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2022-10-15
to 2024-03-31
Research types:
Epidemiological research
Research areas:
General
Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2022-08-01
to 2025-07-31
Research types:
Basic research
Research areas:
Immunological dysfunction, General
Care Model for Patients with ME/CFS (CFS_CARE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2021-12-15
to 2024-12-15
Research types:
Epidemiological research
Research areas:
General, Mental health
Care for ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayer
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Cell Morphology, Cell Deformability and Microclots in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin
Research period:
2024-01-01
to 2026-12-31
Research types:
Basic research
Research areas:
Hemic and lymphatic system disorders, Infections
Chronic Fatigue Syndrome and Immunedeficiencies
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayer
Organisations:
Medical University of Vienna
Research period:
2019-03-01
to not available
Research types:
Basic research
Research areas:
Infections, Immunological dysfunction
Computer-based Clustering of Chronic Fatigue Syndrome Patients (CCCFS)
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayer
Organisations:
Medical University of Vienna
Research period:
2021-03-01
to 2022-03-01
Research types:
Epidemiological research
Research areas:
General
Decreased NO Production in Endothelial Cells Exposed to Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Jennifer Blauensteiner
Organisations:
FH Joanneum University of Applied Sciences
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
Development of Diagnostic Tests to Detect Autoantibodies in CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immunological dysfunction
EBV, SARS-CoV-2, HSV Mimicry Epitopes and Autoantibodies
Project status:
Ongoing
Country:
Germany
Principal investigator:
Franziska Sotzny
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08-01
to 2025-07-31
Research types:
Basic research
Research areas:
Infections, Immunological dysfunction, General
Endothelial Dysfunction and Altered Endothelial Biomarkers in Patients with Post-COVID-19 Syndrome and Chronic Fatigue Syndrome (ME/CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Milan Haffke
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Cardiovascular dysfunction
Endothelial Peripheral Arterial Tonometry (EndoPAT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain
Research period:
2022-10-01
to not available
Research types:
Clinical research
Research areas:
Cardiovascular dysfunction
Establishing Immunological Assays for the Diagnostics of ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immunological dysfunction
Evidence and Effect of Serum Factors in Patients with ME/CFS after COVID-19 on Endothelial Cell Function In Vitro
Project status:
Ongoing
Country:
Germany
Principal investigator:
Kanchan Dulal
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
Experiences of ME/CFS Patients in the German Healthcare System - A Qualitative Study on a Very Special Doctor-Patient Relationship
Project status:
Completed
Country:
Germany
Principal investigator:
Lotte Habermann-Horstmeier
Organisations:
Villingen Institute of Public Health (VIPH)
Research period:
2022-09-01
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
Extracellular Vesicles from Plasma as Potential Biomarkers for an Improved Diagnosis of Endothelial Dysfunction in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Diana Boristowski
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
GaPaMUC-CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2020-09-01
to 2022-06-01
Research types:
Epidemiological research
Research areas:
General
HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS
Project status:
Completed
Country:
Latvia, Germany
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
Not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system disorder, General
Handgrip strength as a marker for muscular fatigue and fatigability in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Bianka Jaekel
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system disorder
Health Care Workers Affected by Long COVID and Exhaustion/Fatigue (HALE Study)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Frauke Mattner
Organisations:
Clinics of the City of Cologne
Research period:
2022-07-04
to not available
Research types:
Epidemiological research
Research areas:
General
Hyperbaric High Pressure Oxygen Therapy (HBOT) in Post-COVID Syndrome and ME/​CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2023-07-15
to 2025-08-31
Research types:
Clinical research
Research areas:
Nervous system disorder, Cardiovascular dysfunction
Identification of Characteristic Biological Factors of a Post-COVID-19 Syndrome (PRAM)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Evelyn Lamy
Organisations:
University Clinic Freiburg
Research period:
2023-06-01
to 2024-05-31
Research types:
Epidemiological research
Research areas:
General
Immune Aberrations in Post-Infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-08-01
to 2025-07-31
Research types:
Basic research
Research areas:
Immunological dysfunction
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS (IA-PACS-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Harald Pruess
Organisations:
Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2023-10-01
to 2025-02-28
Research types:
Clinical research
Research areas:
Immunological dysfunction
Immunoadsorption vs Sham Treatment in Post-COVID-19 Patients With Chronic Fatigue Syndrome (EXTINCT post COVID)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Vega Goedecke
Organisations:
Hannover Medical School (MHH)
Research period:
2023-07-01
to 2025-06-30
Research types:
Clinical research
Research areas:
Immunological dysfunction
Impact of the serum of Post-COVID-Syndrome patients without vs with ME/CFS on endothelial cell function
Project status:
Completed
Country:
Germany
Principal investigator:
Lavinia Flaskamp
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2021-08-01
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system disorder
ME/CFS Biobank Austria
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayer
Organisations:
Medical University of Vienna
Research period:
2023-09-01
to not available
Research types:
Basic research
Research areas:
General
ME/CFS Kids Bavaria
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2021-12-01
to 2023-12-31
Research types:
Epidemiological research
Research areas:
General
ME/CFS Registry and Biobank (MECFS-R & MECFS-Bio)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2022-01-01
to 2024-12-31
Research types:
Epidemiological research
Research areas:
General
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) (PoCoVIT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
2023-10-01
to 2025-03-31
Research types:
Clinical research
Research areas:
Immunological dysfunction, Nervous system disorder
Mitochondrial Dysfunction and Metabolic Changes
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2022-08-01
to 2025-07-31
Research types:
Basic research
Research areas:
Immunological dysfunction, Nutritional and metabolic system disorder
Munich Cohort Study With Biobank for Children, Adolescents, and Young Adults With Post-infection ME/CFS (MUC-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2019-01-22
to 2029-01-01
Research types:
Epidemiological research
Research areas:
General
Observational Study of the Effect of Immunoadsorption (IA) in Patients < 18 Years of Age with ME/CFS with Evidence of Autoantibodies (BIAKI)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfgang Ries
Organisations:
DIAKO Hospital
Research period:
2023-11-01
to 2025-11-30
Research types:
Clinical research
Research areas:
Immunological dysfunction
Occurence and Characterization of the Chronic Fatigue Syndrome in the Berlin Subcohort of the Population-Based NAPKON-POP (COVIDOM) Study
Project status:
Ongoing
Country:
Germany
Principal investigator:
Lilian Krist
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Optical Coherence Tomography Angiography (OCT-A) and Non-invasive Dynamic Vessel Analysis (DVA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain
Research period:
2022-10-01
to not available
Research types:
Clinical research
Research areas:
Cardiovascular dysfunction
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/​CFS (POTS-CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2021-12-06
to 2022-11-22
Research types:
Epidemiological research
Research areas:
Nervous system disorder, Cardiovascular dysfunction
Plasma Extracellular Vesicles as Potential Biomarkers for Endothelial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
Post-COVID-Kids Bavaria 1.0
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends, Michael Kabesch
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM), Barmherzige Brüder Clinic St. Hedwig Regensburg
Research period:
2021-09-15
to 2023-06-30
Research types:
Epidemiological research
Research areas:
General
Post-COVID-Kids Bavaria 2.0
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2023-09-01
to 2024-12-31
Research types:
Epidemiological research
Research areas:
General
Repeat Immunoadsorption Post Covid ME/​CFS (RIA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08-28
to 2025-01-30
Research types:
Clinical research
Research areas:
Immunological dysfunction
Sodium Content in Lower Leg Muscle in Patients with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Elisabeth Petter
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system disorder, Nutritional and metabolic system disorder
Structural and Functional MRI Studies and Accompanying Arterial Spin Labeling (ASL)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain
Research period:
2022-10-01
to not available
Research types:
Clinical research
Research areas:
Nervous system disorder, Cardiovascular dysfunction
Study on Infectious Mononucleosis in Munich (IMMUC)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2017-03-01
to 2025-12-31
Research types:
Epidemiological research
Research areas:
Infections
Study on Long COVID and ME/CFS Symptoms in Patients with Mental Disabilities and the Experiences of Patients, Relatives and Carers in the German Healthcare System
Project status:
Ongoing
Country:
Germany
Principal investigator:
Lotte Habermann-Horstmeier
Organisations:
Villingen Institute of Public Health (VIPH)
Research period:
2022-09-01
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome (VERI-LONG)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Judith Bellmann-Strobl
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC)
Research period:
2023-02-01
to 2024-12-31
Research types:
Clinical research
Research areas:
Cardiovascular dysfunction
The Role of Hidden Viral Infections in Peripheral Blood and Gut-Specific Lymphatic Tissue in the Pathogenesis of ME/CFS (UNRAVELING ME/CFS)
Project status:
Ongoing
Country:
USA, Austria
Principal investigator:
Alexander Zoufaly
Organisations:
Clinic Favoriten Vienna
Research period:
Not available
Research types:
Epidemiological research
Research areas:
Hemic and lymphatic system disorders, Infections, General
Understanding Potential Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
Not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system disorder
Unraveling Endothelial Function in ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular dysfunction
unCOVer Erlangen - ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
Not available
Research types:
Clinical research
Research areas:
Immunological dysfunction