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HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS

About

Status:
Completed
Principal investigator:
Country:
Latvia, Germany
Study start:
Not available
Completion (planned):
Not available
Last update:
2023-11-30

 

Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system disorder, General
Interventions:
Not applicable
Priv. Sector Partner:
Not available
Sponsors:

Project description

Bhupesh Prusty (PhD), a molecular virologist at the University of Wuerberg, designed his Ramsay project to explore the hypothesis that mitochondrial dysfunction in ME/CFS has a pathogenic connection. He focused on HHV-6 (a herpesvirus that has been implicated in chronic conditions) based on his previous findings of HHV-6 activation and changes to mitochondria. Dr. Prusty and his collaborators honed an experimental system to study early stages of viral reactivation. Their work also points to a mechanism that accounts for how, even with a low number of copies of the virus in the blood, HHV-6-infected cells might still impact energy production in adjacent or distant cells through factors secreted in the blood plasma of ME/CFS patients.

(Description adapted from project website: see link above)

Patient cohort

ME/CFS according to Canadian Consensus Criteria (CCC) compared with healthy controls and patients with other clinical conditions.

Patients enrolled: 79

Age group: 21 - 59 years (Adults)

Research areas (9)
Research types (2)
Research networks (0)
Working groups (4)
People (5)
Publications (2)
Organisations (4)

Research areas

Mitochondrial dysfunction
Description:
Mitochondrial diseases are conditions caused by abnormal function of the mitochondira. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes. (Description adapted from: ...
Research projects:
4
Publications:
6
Human herpesvirus 6 (HHV-6)
Description:
Human Herpesvirus 6 (HHV-6) is a member of the roseolovirus genus of the Betaherpesvirales subfamily isolated from patients with AIDS and other lymphoproliferateive disorders. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter the activity of NK cells. HHV-6 antibodies are elevated in patients with AIDS, Sjögre...
Research projects:
3
Publications:
6
General
Description:
General research area that is not attributed to a specific organ dysfunction or research entity.
Research projects:
25
Publications:
34