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POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/​CFS (POTS-CFS)


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Research types:
Epidemiological research
Research areas:
Nervous system disorder, Cardiovascular dysfunction
Active standing test
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Project description

ME/CFS is a complex disease. Symptoms include orthostatic intolerance (OI) such as postural tachycardia syndrome (POTS). POTS in ME/CFS can significantly impair everyday function and social participation. Yet, data in affected adolescents are rare and inconsistent.

This pilot-case-control study study aimed at characterizing OI in adolescents aged 14-17 years with ME/CFS and age-adapted HC, comparing the results with other clinical features of both such as exertion intolerance, fatigue, and health-related quality of life, and suggesting a standardized tool for diagnostics. ME/CFS was diagnosed according to the Clinical Canadian Criteria (CCC 2003), criteria of the former Institute of Medicine (IOM 2015), the diagnostic work sheet developed by Rowe 2017, and/or the pediatric case suggested by Jason 2006. Questionnaires were used to evaluate symptoms (e.g. post-exertional malaise, fatigue, anxiety, depression), and health-related quality of life. A standardised specific interview was performed to assess the medical history of OI (HOI). Heart rate (HR) and blood pressure were evaluated every minute during a passive 10-min standing test (NASA lean test) in the morning with empty stomach and without morning medication.

Data were evaluated according to the POTS criteria defined in 2019 at the National Institutes of Health Expert Consensus Meeting and by the International Classification of Diseases (ICD-11) (8D89.2). Frequency and type of OI, including POTS, were examined in both groups and outcomes compared to parameters from questionnaires. Based on the results, novel standards for OI diagnostics were suggested.

(Description adapted from project website: see link above)

Patient cohort

Post-infectious ME/CFS according to Institute of Medicine (IOM), Canadian Consensus Criteria (CCC), the diagnostic worksheet published by Rowe et al. (2017), or the pediatric case definition published by Jason et al. (2006). Compared with healthy controls.

Patients enrolled: 40

Age group: 14 - 17 years (Children)

Research areas (5)
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Research areas

Nervous system disorder
Nervous system is the entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. Diseases of the nervous system include diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic ner...
Research projects:
Autonomic dysfunction
Diseases of the parasympathetic or sympathetic divisions of the autonomic nervous system, which has components located in the central nervous systems and peripheral nervous system. Autonomic dysfunction may be associated with hypothalamic diseases, brain stem disorders, spinal cord diseases, and peripheral nervous system diseases. Manifestations include impairments of vegetative functions in...
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