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Research areas

This section of the ME/CFS Research Register (beta version) provides an overview of areas of medical research connected with ME/CFS research. By clicking on one of the research areas below, you will be directed to a separate page. There you will find research projects, types, and networks, as well as working groups, selected people, publications and event items connected with the research area. You may also use the search function to look for specific topics or people, for example. A more comprehensive and systematic overview of the research areas listed under this section will be published later. A description of the current scope of the ME/CFS Research Register (beta) can be found on the starting page (Home).
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83 of 83 research areas

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Acid-base disruption
Description:
Acidosis and alkalosis viewed collectively. Acidosis is a pathologic condition of acid accumulation or depletion of base in the body. The two main types of acidosis are respiratory acidosis and metabolic acidosis, due to metabolic acid build up. Alkalosis is a pathological condition that removes acid or adds base to the body fluids. The two main types of alkalosis are respiratory alkalosis a...
Research projects:
0
Publications:
1
Angiotensin-converting enzyme 2 (ACE2)
Description:
A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with Angiotensin II as a substrate than with Angiotensin I. ACE2 is also is a functional receptor for the spike glycoprotein of the SARS-CoV, SARS-CoV-2, and HCOV-NL63...
Research projects:
0
Publications:
2
Autonomic dysfunction
Description:
Diseases of the parasympathetic or sympathetic divisions of the autonomic nervous system, which has components located in the central nervous systems and peripheral nervous system. Autonomic dysfunction may be associated with hypothalamic diseases, brain stem disorders, spinal cord diseases, and peripheral nervous system diseases. Manifestations include impairments of vegetative functions in...
Research projects:
1
Publications:
5
Brain
Coagulation abnormalities
Description:
Blood coagulation describes the process of interaction of blood coagulation factors that results in an insoluble fibrin clot. Blood coagulation disorders describe hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as coagulation protein disorders, blood platelet disorders, blood protein disorders or nutritio...
Research projects:
1
Publications:
1
Endothelial dysfunction
Description:
Endothelium is a layer of epithelium that lines the heart, blood vessels, lymph vessels, and the serous cavities of the body. The endothelium maintains an adequate homeostasis via its capacity to produce protective molecules. When this function is lost or damaged, endothelial dysfunction occurs, leading to a reduction in the capacity to maintain homeostasis and the development of pathologica...
Research projects:
10
Publications:
8
Epstein-Barr virus (EBV)
Description:
Epstein-Barr virus (EBV) is the type species of lymphocryptovirus, belonging to the subfamily of gammaherpesvirinae, infecting B-cells in humans. It is thought to be the causative agent of inectious mononucleosis (IM) and is strongly associated with oral hairy leukoplakia, burkitt lymphoma and other malignancies. IM is a common, acute infection usually caused by EBV. There is an increase in ...
Research projects:
6
Publications:
10
Fibronectin
G protein-coupled receptor (GPCR) autoantibodies
General
Description:
General research area that is not attributed to a specific organ dysfunction or research entity.
Research projects:
25
Publications:
32
Genetic risk factors
Description:
Genetic risc factors refer to the probability of an individual orgnanism carrying a specific disease-associated mutation, or of being affected with a specific genetic disorder. Genomics is the systematic study of the complete DNA sequences (genome) of organisms. It includes the construction of complete genetic, physical, and transcript maps, and the analysis of this structural genomic inform...
Research projects:
1
Publications:
5
Gut-brain axis
Description:
An interactive network between the gastrointestinal tract (gut) and the brain principally mediated through the enteric nervous system. Control of the gut activities during stress, for instance, is mediated by activation of neuroendocrine hormones. Conversely, intestinal microbiota associate with the central nervous system through the axis via microorganism-derived products. Some functional g...
Research projects:
0
Publications:
2
Hemic and lymphatic system disorders
Human herpesvirus 6 (HHV-6)
Description:
Human Herpesvirus 6 (HHV-6) is a member of the roseolovirus genus of the Betaherpesvirales subfamily isolated from patients with AIDS and other lymphoproliferateive disorders. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter the activity of NK cells. HHV-6 antibodies are elevated in patients with AIDS, Sjögre...
Research projects:
3
Publications:
6
Immunological dysfunction
Description:
Immune system is the body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-m...
Research projects:
17
Publications:
40
Mitochondrial dysfunction
Description:
Mitochondrial diseases are conditions caused by abnormal function of the mitochondira. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes. (Description adapted from: ...
Research projects:
5
Publications:
6
Nervous system disorder
Description:
Nervous system is the entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. Diseases of the nervous system include diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic ner...
Research projects:
5
Publications:
11
Other
Description:
Research area that is not attributed to a specific organ dysfunction or research entity.
Research projects:
0
Publications:
4
Polytropic murine leukemia viruses (pMLV)
Description:
Murine leukemia viruses (MLV) are a species of gammaretroviruses, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. Polytropic murine leukemia viruses (MLVs) are generated by recombination of ecotropic MLVs with members of a family of endogenous proviruses in mice. (Description adapted ...
Research projects:
0
Publications:
1
Renin angiotensin aldosteron system (RAAS)
Description:
A blood pressure regulating system of interacting components that include renin, angiotensinogen, engiotensin, converting enzyme; angiotensin I, angiotensin II, and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in th...
Research projects:
0
Publications:
2
Small fibre neuropathy (SFN)
Description:
Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (A fibres) and unmyelinated C fibres. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweatin...
Research projects:
0
Publications:
2
Small non-coding RNA